Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.

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Kyoto Encyclopedia of Genes and Genomes More National Institutes of Health. Q95Q98 Primary citable accession number: You are entitled to post or upload the Material on the website and have all necessary licenses and consents to do so; the Material does not infringe any intellectual property right, including without limitation copyright, patent or trademark, or other proprietary right of any third party; the Material does not contain any defamatory, libellous, offensive, indecent or otherwise unlawful material or material which is an invasion of privacy; the Material does not contain any contaminating or destructive features or devices such as viruses, time bombs or coding designed to interrupt, destroy or limit the functionality of this website or any of this website’s user’s computer equipment or software; the Material will not be used to solicit or promote business or custom or present commercial activities or unlawful activity; and the Material is in compliance with all applicable laws.

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Showing of extracted citations. See the description of this molecule in ChEBI. TranscriptionTranscription regulation. Encyclopedia of Proteome Dynamics More Eukaryotic Ortholog Jmjc-domain-contaihing More F reserves the right to remove any comments that it considers in its absolute discretion to be inappropriate, offensive or otherwise in breach of the Terms and Conditions relating to Materials including Comments. Search chemical reactions in Rhea for this molecule.


Emerging Roles of JmjC Domain-Containing Proteins.

However, one subgroup remains, the largest, in which the JmjC domain has no known biochemical function. Select a section on the left to see content.

You have a close personal relationship e. FPrime is an expert-curated resource to help you find the articles of greatest interest and relevance to you. Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein prkteins mechanism that is conserved from yeast to human.

Has a role in regulating lifespan. Select item s and click on “Add to basket” to create your own collection here entries max. Contributing signatures Signatures from InterPro member databases are used to construct an entry.

Database of Orthologous Groups More Show all Align All Isoform a identifier: Manual assertion based on experiment in i.

Hypoxia-Inducible Histone Lysine Demethylases: Don’t have an account? These terms shall be governed by and construed in accordance with English Law. The sequence of this isoform differs from the canonical sequence as follows: I would jmjc-domain-contsining to receive updates when further comments, recommendations, jmjc-doamin-containing dissenting opinions are publishing on this article. Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.

Show all Align All. hietone

Expanding role of the jumonji C domain as an RNA hydroxylase. Showing of references. Material does not reflect the views or opinions of F, its agents or affiliates. Non-supervised Orthologous Groups More Four distinct tokens exist: It is useful for tracking sequence updates. N 6N 6 -dimethyl- L -lysine residue. Differential intron retention in Jumonji chromatin modifier genes is implicated in reptile temperature-dependent sex determination Ira W.


JmjC domain (IPR) < InterPro < EMBL-EBI

Skip to search form Skip to main content. Consider the following examples, but note that this is not an exhaustive list:. It lists the jmjc-doomain-containing as they appear top-down in the taxonomic tree, with the more general grouping listed first. Whereas most covalent histone modifications are reversible, until recently it was unknown whether methyl groups could be actively removed from histones.

Enzymes that directly remove methyl marks from histones have recently been identified, proteinz a new level of plasticity within this epigenetic modification system.

JmjC-domain-containing proteins and histone demethylation.

Belongs to the JHDM1 histone demethylase family. See the description of this reaction in Rhea. In the best studied JmjC-domain proteins, the JmjC barrel has a histone demethylase catalytic activity. Topics Discussed in This Paper. Hiztone disclose any competing interests that might be construed to influence your judgment of the validity or importance of the article, or any recommendation or review.

No experimental confirmation available.

March 1, Last modified: The cupin fold is a flattened beta-barrel structure containing two sheets of five antiparallel beta strands that form the walls of a zinc-binding cleft. Register Already registered with FPrime?